Cichlasoma urophthalmus are large cichlids that produce a lot of waste and require a lot of space. That said its best to keep Mayan cichlids with other large fish of the same temperament.
Never keep Mayan cichlids with smaller tank mates because they will be tempted to eat them.
A 55 US Gallon aquarium should the minimum size tank for C. urophthalmus.
Larger tanks are preferred to house these cichlids such as 70, 100, 120, or even 150 US Gallon tank.
Some decent potential tank mates would be other Central American Cichlids, such as the Red Devil complex including Midas Cichlids, Amphilophus citrinellus, and Amphilophus labiatus. Other possible tankmates include Theraps species like the Black Belt Cichlid or Theraps maculicauda, the Redheaded Cichlid Cichlid, Theraps synspilum, and the Redspotted Cichlid, Theraps bifasciatum.
Other tropical fishes that may be compatible with Nandopsis urophthalmus are large freshwater catfishes, such as the suckermouth armoured catfish of the Loricariidae family. This family includes favourite aquarium denizens like Hypostomus plecostomus, Pterygoplichthys pardalis and other plecostomus species.
Its sugggested not to house Mayan Cichlids with members of the Nandopsis group, such as the Wolf Cichlid, Parachromis dovii, the Jaguar Cichlid, Parachromis managuensis, or the Motagua Cichlid, Parachromis motaguensis. This due to their close relations and all of these cichlids will fight each other for territory and for dominance.